Senior Clinical Pharmacologist

The purpose of Idorsia is to challenge accepted medical paradigms, answering the questions that matter most. To achieve this, we will discover, develop, and commercialize transformative medicines – either with in-house capabilities or together with partners – and evolve Idorsia into a leading biopharmaceutical company, with a strong scientific core.

We are seeking an experienced, entrepreneurial Senior Clinical Pharmacologist to join our organization. In this role, you will operate in a lean, fast-paced environment with established core processes and systems, influencing the clinical pharmacology strategy across a high volume of First-in-Human (FIH) and early clinical programs, as well as ongoing studies.

This is a hands-on, high-impact role within Global Clinical Development, offering significant visibility and growth potential in the organization, and requiring close collaboration with Translational Research.

Key Responsibilities

• Lead the design and execution of clinical pharmacology strategies and corresponding studies across multiple programs,
• Develop innovative and meaningful clinical pharmacology approaches that accelerate and de-risk drug development
• Define dose selection, escalation strategies, and characterize exposure-response relationships
• Ensure integration of nonclinical, translational, biomarker and clinical data to inform development decisions

• Design clinical studies with appropriate pharmacokinetic (PK) and pharmacodynamic (PD) endpoints
• Apply biomarkers and model-informed drug development (MIDD) approaches to enhance study design and decision-making
• Author and contribute to protocol development, including statistical and modeling/simulation considerations
• Serve as the primary clinical pharmacology interface with: Research, Translational Sciences, Biostatistics, Regulatory Affairs

• Represent clinical pharmacology at life cycle meetings
• Lead scientific discussions and provide strategic input in program governance meetings and decision-making forums

• Manage a large inflow of new clinical candidates alongside ongoing studies
• Author and contribute to regulatory documentation (IND/CTA, briefing documents, health authority responses)

• Represent clinical pharmacology in agency interactions as a subject matter expert
• Manage and oversee external partners (CROs, modeling vendors)

Qualifications & Experience

• PhD, PharmD, MD, or equivalent in Clinical Pharmacology, Pharmacokinetics, or related field
• 10+ years of job relevant industry experience in biotech/pharma
• Proven track record in:
  • Early clinical development (FIH through proof-of-concept)
  • Study design and dose justification
  • PK/PD modeling and interpretation
• Experience managing multiple concurrent programs in a dynamic environment

• Entrepreneurial mindset and intellectual curiosity with ability to thrive in ambiguity and rapid change
• Strong scientific leadership with a hands-on, execution-oriented approach
• Demonstrated ability to translate clinical pharmacology data into high-quality manuscripts, abstracts, and conference presentations
• Excellent cross-functional collaboration and influencing skills
• Ability to balance strategic thinking with operational delivery

Why Join Us?

• Join a science-led organization with a proven track record of innovative medicines from discovery to launch
• Opportunity to work on multiple innovative early-stage programs with a high level of ownership and visibility across the organization
• Thrive in an agile and entrepreneurial culture that champions innovative development over bureaucracy