PhD Researcher - Agentic AI

Project background

The Singapore-ETH Centre was established in 2010 by ETH Zurich - The Swiss Federal Institute of Technology and Singapore’s National Research Foundation (NRF), as part of the NRF’s CREATE campus. As ETH Zurich's only research centre outside of Switzerland, the centre has strengthened the research capacity of ETH Zurich to develop sustainable solutions to global challenges in Switzerland, Singapore and the surrounding regions.

Set in Asia, in a rapidly urbanising region, the Singapore-ETH Centre aims to provide practical solutions to some of the most pressing challenges on urban sustainability, resilience and health through its programmes: Future Cities Lab Global (FCL Global) and Future Health Technologies (FHT).

The centre serves as an intellectual hub for research, bringing together principal investigators and researchers from diverse disciplines and backgrounds. To promote the exchange of ideas and expertise, our researchers actively collaborate with universities and research institutes and engage with industry and government agencies to translate knowledge to practical solutions to real-world problems.

The increasing availability of multimodal health data, coupled with advances in AI, offers new opportunities to deliver personalised, scalable behavioural interventions in healthcare. However, current conversational AI systems remain limited in their ability to operate reliably across diverse clinical contexts. They often lack generalisability, struggle to integrate heterogeneous and longitudinal data, and do not adequately address key challenges related to safety, bias, robustness, and clinical validity.

We are seeking a highly motivated PhD candidate to join an interdisciplinary Future Health Technologies (FHT) research programme at the forefront of agentic AI in healthcare. The project aims to design, develop, and evaluate AI-driven coaching and nudging systems capable of supporting positive patient outcomes across a range of conditions.

The successful candidate will contribute to the development of a scalable and interoperable AI system that delivers personalised behavioural support across domains such as mental well-being, stroke rehabilitation, falls prevention, and chronic disease management. Central to this work is the integration of multimodal data ingestion, knowledge retrieval, and adaptive decision-making to deliver high-quality health/ behaviour change interventions with a strong emphasis on performance, safety, and real-world applicability.

By bridging machine learning, behavioural science, and clinical research, the project seeks to establish foundational methods for trustworthy agentic AI systems that can be deployed across diverse healthcare settings.

Job description

The PhD will form part of a broader interdisciplinary research programme in mobile health and AI, with applications in areas such as mental well-being, fall prevention, stroke rehabilitation, and chronic disease prevention. The PhD student will work in an interdisciplinary team spanning behavioural scientists, clinical psychologists, computer scientists, AI engineers, and health systems researchers. The position involves close collaboration with research partners in Singapore, including Nanyang Technological University, National University of Singapore, Tan Tock Seng Hospital (TTSH) and Duke-NUS Medical School, as well as public health and healthcare stakeholders.

The PhD student will be responsible for designing, developing, and validating a comprehensive agentic AI platform that supports multimodal data ingestion, knowledge retrieval, and LLM-based workflows for the delivery of evidence-based coaching strategies, including motivational interviewing. This includes analysing time-series data from smartphone sensors and usage logs using advanced statistical and machine learning approaches to develop personalised nudging and adaptive interventions. The candidate will also lead the development of a cross-platform mobile application for delivering and monitoring these interventions, including deployment and management of the associated backend infrastructure.

The PhD student will work in close partnership with researchers developing hardware interfaces for device data ingestion and will support clinical validation studies to evaluate the feasibility, acceptability, and effectiveness of the developed interventions with end-users and key stakeholders. The candidate will also contribute to ethics submissions, data governance documentation, and analysis plans in accordance with Singaporean and international research standards.

The role involves publishing findings in high-impact peer-reviewed journals and presenting at leading international conferences. Given the applied, translational nature of the project, the position offers exceptional opportunities for professional development and for contributing to healthcare innovations with direct real-world impact across domains including mental well-being, stroke rehabilitation, falls prevention, and chronic disease management.

Profile

• Applicants must hold a Master’s degree (or be near completion) in Computer Science, Software Engineering, Informatics, Information Systems, or a closely related discipline.
• A strong theoretical and practical foundation in machine learning is essential, encompassing both the underlying principles, such as model evaluation and data pipelines, and their applied forms, including training, fine-tuning, and deployment of models using frameworks such as PyTorch or TensorFlow.
• Solid proficiency in Python and a genuine interest in applying AI to real-world healthcare challenges are required.
• Prior experience integrating Large Language Models (LLMs) into applications, including prompt engineering, API integration, or retrieval-augmented generation, is a significant advantage.
• Candidates must demonstrate strong previous experience in software and application development, ideally including the design or prototyping of mobile health (mHealth) applications.
• Familiarity with cross-platform frameworks such as React Native (frontend) and Django or FastAPI (backend) is expected, alongside proficiency in Python and JavaScript/TypeScript.
• Knowledge of cloud platforms such as AWS for deployment is a further advantage.
• The successful candidate must demonstrate excellent analytical and problem-solving skills, strong written and spoken communication in English, and the capacity to work both independently and collaboratively within a large, international, multidisciplinary team.
• A genuine motivation to engage with interdisciplinary partners, including clinicians, behavioural scientists, software engineers, community organisations, and patients, and to pursue rigorous, translational research with direct clinical impact is essential.

We offer

• Accredited with 5 Tripartite Standards by Tripartite Alliance for Fair & Progressive Employment Practices (TAFEP) Singapore. 
• A diverse workplace with 32 nationalities, offering ample opportunities for mutual learning. 
• Positive and inclusive working environment. 
• 25 days of annual leave for fixed-term contracts. 
• 1 day of Birthday Leave. 
• Annual dental benefits. 
• Committed to being a supportive employer as you prioritize your physical and mental wellness. 
• Comprehensive healthcare insurance coverage. 
• Flexible hybrid work arrangement (up to 2 days per week from home). 
• Abundant networking opportunities across various disciplines. 
• Accredited with NS mark certification. 

Singapore-ETH Centre

The Singapore-ETH Centre provides a multicultural and interdisciplinary environment to researchers working on diverse themes focussed on sustainable and liveable cities, resilient urban systems, and patient-centric healthcare. The centre is home to a community of over 100 doctoral, postdoctoral and professorial researchers working in three main programmes: Future Cities Laboratory, Future Resilient Systems, and Future Health Technologies.